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Biosci Rep

Scope of Guthione: undesired (incl

Mark the camera position to ensure reproducibility

doi: 10.1016/j.biopha.2022.112879 85 RenYLiSSongZLuoQZhangYWangH

Its defining structural feature is the gamma-glutamyl linkage: the glutamate residue is joined through its side-chain carboxyl rather than the usual alpha-peptide bond, which makes the molecule resistant to most intracellular peptidases and means it is cleaved almost exclusively by gamma-glutamyl transpeptidase at the outer cell surface (Zhang, Forman and Choi, Methods in Enzymology, 2005)

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